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Lympha™ Evidence Library

The science behind Lympha

Lympha is built around clinically studied actives — disclosed by name and amount, and selected at daily levels informed by the strongest available human research.

Lympha daily tincture in its amber glass bottle.

The thesis

Tissue-fluid balance is shaped by more than the lymphatic system alone. Venous return, capillary filtration, barrier integrity, and microcirculatory exchange all influence how much fluid enters the tissue environment and how much the body must manage over time. Lympha is formulated around that broader system.

Not a proprietary blend

Built differently from the category

Most lymphatic supplements rely on proprietary blends, traditional botanicals, or ingredients used without clear dose context. Lympha discloses every active and every amount, selected for human-research relevance across venous tone, capillary integrity, microcirculation, and tissue-fluid balance.

Five clinically studied actives.
One fluid-balance system.

01 Micronized diosmin MPFF pair
02 Hesperidin MPFF pair
03 OPC-rich grape seed extract ≥95% OPCs
04 Centella asiatica Triterpene-standardized
05 Butcher’s Broom 10:1 extract

At a glance

Ingredient evidence map

A quick view of the human evidence behind each active, what those studies measured, and how each ingredient informs Lympha’s system-level formula.

Evidence strength by active ingredient
Active Human evidence depth What the studies tracked How it informs Lympha
Diosmin + hesperidin (MPFF) Robust Lower-limb circumference, swelling sensation, leg comfort, quality of life The formula’s strongest clinical anchor; Lympha mirrors the classic 450 mg diosmin + 50 mg hesperidin MPFF ratio
Grape seed extract Supportive Leg swelling under prolonged sitting, venous comfort, quality of life The clearest bridge to everyday strain: healthy women, prolonged sitting, and measured leg-fluid changes
Centella asiatica Supportive Capillary filtration, microcirculatory flow, leg volume Direct human microvascular and leg-volume measurements at the capillary–interstitial interface
Butcher’s broom Supportive, preparation-dependent Leg volume, ankle circumference, heaviness Anchored by standalone human trial evidence; Lympha uses a concentrated 10:1 Butcher’s Broom extract

Evidence depth reflects the volume and consistency of human research behind each ingredient or standardized preparation — not effect size or a finished-product claim. Lympha is evidence-informed: the ingredients have been studied; the finished formula has not been independently clinically tested.

Everyday use

Built for everyday strain

Long sits.
Travel.
Desk days.

The everyday load on fluid balance

The systems Lympha supports — venous return, capillary integrity, and microcirculatory exchange — carry the most load during the ordinary situations people actually feel: hours at a desk, a long flight, a day on your feet.

One of the clearest reads on that load comes from a placebo-controlled crossover study, in which an OPC-rich grape seed extract was associated with less lower-leg swelling during prolonged sitting — the everyday strain, measured directly.*

*Evaluates a single standardized ingredient, not the finished Lympha formula. Structure/function support; not intended to diagnose, treat, cure, or prevent any disease.

Per-ingredient detail

Evidence library

Each active is disclosed by name and amount, then mapped to the human research that informed its role in the formula. Expand any ingredient to view representative studies and formulation context.

Diosmin and hesperidin are citrus-derived bioflavonoids most often studied together as micronized purified flavonoid fraction (MPFF), a 9:1 diosmin-to-hesperidin format with an unusually deep human clinical record. In Lympha, this pair anchors the venous-comfort and microcirculatory side of the formula — systems that influence how fluid is carried, filtered, and managed in tissue.

What the human research shows

Objective fluid-balance measures

A 2023 systematic review and meta-analysis of prospective MPFF studies reported mean circumference reductions of about 6.0 mm (ankle) and 5.7 mm (calf) at ~2 months, sustained at about 7.0 mm and 6.7 mm by ≥6 months. These are objective circumference measures, not symptom-only outcomes.[1]

Symptoms and quality of life

Controlled trials using the Daflon 500 mg format report improvements versus placebo in heaviness, discomfort, cramps, and “feeling of swelling,” with quality-of-life scores improving alongside.[2]

Large-scale, real-world signal

In RELIEF (n ≈ 5,052; 6 months; no placebo control), MPFF use tracked with progressive symptom and quality-of-life improvement (CIVIQ), with edema measured by leg circumference. Although observational, it adds time-course and scale.[3]

Depth of the clinical record

The diosmin–hesperidin evidence base spans a broad range of venous-health research contexts — a depth few ingredients in this category can match.[4]

Research context

Much of the pooled circumference literature uses 1000 mg/day MPFF and was conducted in chronic venous disease populations. Lympha uses the classic 450 mg diosmin + 50 mg hesperidin ratio as part of a broader daily fluid-balance formula.

Dose in Lympha
450 mg + 50 mg / day
Studied format
MPFF (9:1 with hesperidin)
Measured endpoints
Ankle/calf circumference, symptom scores, QoL, severity indices
Role in the system
Venous comfort · microvascular function · fluid-balance context

Grape seed extract (Vitis vinifera), standardized for oligomeric proanthocyanidins (OPCs), provides polyphenols studied for microvascular integrity and fluid handling under circulatory strain. Excess interstitial fluid often starts at the capillary level, and OPC-rich extracts are studied in models where those fluid shifts can be measured directly.

What the human research shows

Prolonged-sitting model — placebo-controlled crossover

In a double-blind, placebo-controlled crossover study in healthy women, an OPC-rich grape seed extract significantly suppressed leg-volume distension, extracellular fluid, and leg water during a 6-hour sit versus placebo — fluid accumulation under everyday strain, measured directly.[5]

Venous-comfort model — noninferiority vs MPFF

In a double-blind randomized trial (n=303; CEAP 1–3), Vitis vinifera seed extract was noninferior to MPFF for venous quality of life (CIVIQ-20) at 8 weeks — meaning the difference stayed within a pre-set margin, not that the two were shown identical. Both groups improved; calf circumference fell from baseline in the seed-extract group.[6]

Venous reflux model — objective endpoint

A 2025 randomized controlled trial in adults with Doppler-confirmed varicose veins found grape seed extract plus lifestyle measures improved venous reflux time, clinical severity, and quality of life over 12 weeks versus lifestyle measures alone — a modern, objective venous-function endpoint.[7]

Research context

Grape seed studies vary by extract profile, dose, and population. Lympha uses a 200 mg extract standardized to ≥95% OPCs, selected for its role in capillary integrity and fluid handling under strain.

Dose in Lympha
200 mg / day
Standardization
≥95% OPCs
Measured endpoints
Leg swelling/volume, reflux time, symptom & severity scales, QoL
Role in the system
Capillary integrity · venous function · fluid handling under strain

Centella asiatica’s active triterpenes — asiaticoside, madecassoside, and related compounds — are studied in humans as standardized fractions (TTFCA / TECA), not as a generic botanical. Its strongest data is at the capillary–interstitial interface, where tissue-fluid balance is largely decided.

What the human research shows

Capillary filtration — placebo-controlled, dose-ranging

A randomized placebo-controlled dose-ranging trial in venous hypertension tested the triterpene fraction at 90 and 180 mg/day over 4 weeks. Capillary filtration rate fell on treatment (not placebo), with ankle measures improving alongside — more at the higher dose.[8]

Microcirculation, oxygenation & volumetry

A prospective placebo-controlled study (120 mg/day; 6 weeks) used laser Doppler, transcutaneous O2/CO2, and leg volumetry — leg volume fell ~66 mL versus minimal placebo change, with microcirculatory measures improving. Objective physiology, not just symptom scales.[9]

Symptoms & venous distensibility

A 2-month multicenter double-blind trial of TECA (60 and 120 mg/day) improved heaviness and edema ratings versus placebo, with venous distensibility improving on TECA while worsening on placebo. This adds symptom and vascular-function context to the microcirculatory findings.[10]

Systematic review context

A systematic review in chronic venous insufficiency concluded Centella may support microcirculatory and swelling-related measures across the available human literature.[11]

Research context

The most relevant human data is tied to standardized triterpene fractions such as TTFCA and TECA. Lympha uses Centella standardized to 40% triterpenes, delivering approximately 90 mg total triterpenes per serving.

Dose in Lympha
225 mg / day (≈90 mg triterpenes)
Standardization
40% total triterpenes
Measured endpoints
CFR, ankle measures, microcirculatory flow, tissue oxygenation, leg volume, distensibility
Role in the system
Capillary permeability · microcirculation · exchange environment

Butcher’s Broom (Ruscus aculeatus) is a traditional European venous-support botanical carrying ruscogenin-related actives. Its human evidence is preparation-dependent, but clinically relevant: Butcher’s Broom anchors the venous-tone side of Lympha’s fluid-balance strategy.

What the human research shows

Standalone placebo-controlled trial — 12 weeks

A 12-week randomized, double-blind, placebo-controlled trial in women with chronic venous insufficiency (Widmer I–II) found a Ruscus preparation reduced integrated edema by about 827 mL·day versus placebo, with leg volume roughly 20 mL lower by week 12 and heaviness and tension improving. The cleanest standalone Ruscus trial here.[12]

Broader evidence base — meta-analysis

A meta-analysis of randomized, double-blind, placebo-controlled trials of Ruscus-containing venous-support preparations found improvements in pain, heaviness, feeling of swelling, ankle circumference, and lower-limb volume — though the pooled literature spans different preparations, some of them combination formulas.[13]

Tolerability

Across these studies, Ruscus-containing preparations were generally well tolerated, though this depends on the specific preparation.[12][13]

Research context

The standalone human evidence is narrower than MPFF, and broader Ruscus literature includes combination preparations. Lympha uses a concentrated 10:1 Butcher’s Broom extract to support the venous-tone side of the formula.

Dose in Lympha
150 mg / day (10:1 extract)
Clinical context
Preparation-dependent human evidence in venous-support settings
Measured endpoints
Leg volume, ankle/calf circumference, heaviness, tension
Role in the system
Venous tone · objective fluid-balance measures · leg comfort

Scientific context

How to interpret this research

01

Ingredient-level evidence

Studies evaluate individual ingredients or standardized preparations — not finished Lympha.

02

Relevant physiological endpoints

Human studies often measure circumference, limb volume, capillary filtration, microcirculatory flow, and quality of life.

03

Evidence varies by preparation

Dose, standardization, study design, population, and duration all affect interpretation.

For scientific context

Additional clinical background

Some literature on these ingredients sits in medical populations, combination preparations, or adjunctive-care settings. It’s included here for scientific completeness, and is not the basis for any of Lympha’s structure/function claims.

  1. [A] A Ruscus-based combination preparation (Ruscus extract with hesperidin methyl chalcone) studied in secondary lymphedema, in which all participants also received manual lymphatic drainage. Reflects a combination product and an adjunctive-care setting — included for context only, not as a basis for any Lympha claim. PubMed:8721977

Sources

Selected human clinical references

  1. [1] Reduction of lower-limb edema in patients with chronic venous disease by micronized purified flavonoid fraction: a systematic literature review and meta-analysis. PubMed:38131655
  2. [2] Daflon 500 mg: symptoms and edema clinical update. PubMed:16193223
  3. [3] Chronic venous insufficiency: worldwide results of the RELIEF study (Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids). PubMed:12025911
  4. [4] Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. PubMed:15936227
  5. [5] Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. PubMed:22752876
  6. [6] Vitis vinifera seed extract versus micronized purified flavonoid fraction for patients with chronic venous disease: a randomized noninferiority trial. PubMed:39009117
  7. [7] Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial. PubMed:41242464
  8. [8] Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. PubMed:11666125
  9. [9] Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. PubMed:11666123
  10. [10] Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. PubMed:3544968
  11. [11] A systematic review of the efficacy of Centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency. PubMed:23533507
  12. [12] Efficacy and safety of a Butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. PubMed:12040966
  13. [13] Efficacy of Ruscus extract, HMC and vitamin C, constituents of Cyclo 3 fort®, on improving individual venous symptoms and edema: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. PubMed:28225220